Time-course global proteome analyses reveal an inverse correlation between Aβ burden and immunoglobulin M levels in the APPNL-F mouse model of Alzheimer disease.

This distribution, which was determined on the basis of 27 separately quantified PSM, was unique for IGHM and was independently observed by both the PEAKS and Proteome Discoverer algorithms, distinguishing it with a highly significant p -value from all other proteins in the volcano plot (blue arrowhead, Fig 2d ) and in box plots summarizing TMT ratios of other robustly quantified proteins ( Fig 4b ).

also in 132,142 other papers