Results from ¹¹C-metformin-PET scans, tissue analysis and cellular drug-sensitivity assays questions the view that biguanides affects tumor respiration directly.

We did observe a borderline significant increase in FDG retention in the highly sensitive A549 tumor model (Fig. 6 ), but this was not a compensatory glycolytic stimulation caused by inhibition of tumor respiration, since tumor hypoxia was unaffected.

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