A review of oral cannabinoids and medical marijuana for the treatment of chemotherapy-induced nausea and vomiting: a focus on pharmacokinetic variability and pharmacodynamics.

Since publication of this initial report, numerous clinical studies have examined the antiemetic efficacy of oral dronabinol or nabilone capsules for the treatment of patients with CINV, with two meta-analyses reporting significant improvements with cannabinoids compared with conventional antiemetic therapy [ 23 , 24 ], and one meta-analysis finding that, while the antiemetic efficacy of cannabinoids was favored, compared with the antiemetic prochlorperazine for the resolution of nausea, vomiting, or nausea and vomiting (Table 1 ), the findings did not achieve significance [ 25 ].

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