an increasing trendP <.001
Similar to the derivation cohort, there was an increasing trend from Trajectory 1 to 3 in terms of severe exacerbation rate in the first year (median 1 vs. 2 vs. 4, Jonckheere‐Terpstra test, P <.001), depression (1.6% vs 5.9% vs 25.0%, linear‐by‐linear P =.026), history of near‐fatal asthma (9.5% vs. 41.2% vs. 50.0%, linear‐by‐linear P =.001), and GERD (14.3% vs. 17.6% vs. 75.0%, linear‐by‐linear P =.020).