In DOCA-salt rats, there was a significant decrease in α-MHC mRNA compared with UNX rats, whereas in serelaxin-treated rats, there was a trend toward an increase that did not achieve significance (Fig. 1a ). β-MHC expression was significantly increased in DOCA-salt rats but reduced in the presence of serelaxin (Fig. 1b ).
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Serelaxin improves cardiac and renal function in DOCA-salt hypertensive rats.
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