Intravenous Fluid Challenge Decreases Intracellular Volume: A Bioimpedance Spectroscopy-Based Crossover Study in Healthy Volunteers.

Intracellular volume was borderline significant (p = 0.052) at the uncorrected level alpha = 0.05, whereas total body volume was not significant but still had a fairly small p-value of p = 0.083.

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Applying a multiple testing procedure would not change the inference from our data analysis: The differences of the area under the curve for fluid load, relative fluid load and extracellular volume between the two groups remain highly significant even after Bonferroni correction for having tested five different outcome variables.

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