Parkinson's disease is associated with DNA methylation levels in human blood and saliva.

Genome Med · 2017 · PMC5576382 · PMID 28851441

Europe PMC DOI

hedged sentences

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp = 4.3 × 10 –10actually significant

Similarly, hypomethylation in PD cases can be observed for two highly significant CpGs in immune-related genes cg04772575 in ABCB9 ( p = 4.3 × 10 –10 ) and cg11334709 in C1orf200 ( p = 7.5 × 10 –10 ).

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borderline significantno p-value reported

Additionally, two modules were borderline significant and enriched for genes related to the mitochondrial envelope membrane.

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borderline significanceno p-value reported

DNA methylation in blood with adjustment for blood cell composition After adjusting for blood cell composition, we generated 97 modules with only one significant PD-associated module after Bonferroni correction and two modules with borderline significance (Additional file 1 : Figure S4a–d).

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