Bi-directional and shared epigenomic signatures following proton and ⁵⁶Fe irradiation.

In addition, there was a trend towards a higher percentage of Arc -positive neurons expressing Arc mRNA in the nucleus and cytoplasm in the CA3 region of the hippocampus following exposure twice to the same environment, as opposed to exposure to two different environments in sham-irradiated mice but that difference was just short of significance ( t = 1.796, p = 0.0578, Fig. 4D ).

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Moreover, this novel DHR subset is associated with a marked increase in intragenic DHR density and highly significant enrichment for genes associated with the postsynaptic specialization demonstrating remarkable specificity for the response to proton irradiation.

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