K-Ras mutation and amplification status is predictive of resistance and high basal pAKT is predictive of sensitivity to everolimus in biliary tract cancer cell lines.

Separation of the cell lines as K‐Ras mutant/amplified versus WT demonstrated increased sensitivity of the WT lines at all three concentrations of everolimus examined, although the 5 n m group narrowly missed statistical significance ( P = 0.053) (Fig. 2 D). 3.4 Activation of the PI3K/PTEN/AKT pathway and everolimus response We next determined whether the activation status of the PI3K/PTEN/AKT pathway was predictive of everolimus response.

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