How Effective Is Algorithm-Guided Treatment for Depressed Inpatients? Results from the Randomized Controlled Multicenter German Algorithm Project 3 Trial.

Int J Neuropsychopharmacol · 2017 · PMC5581493 · PMID 28645191

Europe PMC DOI

hedged sentences

0.0550

closest p · 1.1× alpha

0.0550

boldest claim

The sentences

narrowly missed statistical significanceP =.055so close (0.05 < p ≤ 0.1)

Compared with TAU, subsequent Cox regression analysis showed that the probability for remission was significantly higher for ALGO DE (HR=1.67 [95%CI 1.11–2.52] Wald test=6.03, P =.014) and for ALGO SW (HR=1.64 [95%CI 1.10–2.48] Wald test=5.60, P =.018), but narrowly missed statistical significance for ALGO LA (HR=1.49 [95%CI 0.99–2.25] Wald test=3.69, P =.055), while there was no difference for time to remission between CDES and TAU (HR=1.06 [95% CI 0.68–1.63], Wald test=0.06, P =.811) (HR=1.06 [95% CI 0.68–1.63], Wald test=0.06, P =.811).

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a nonsignificant trendno p-value reported

Our results show a shorter time to remission for ALGO DE and ALGO SW but only a nonsignificant trend for ALGO LA compared with CDES and TAU.

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