High titers of both rheumatoid factor and anti-CCP antibodies at baseline in patients with rheumatoid arthritis are associated with increased circulating baseline TNF level, low drug levels, and reduced clinical responses: a post hoc analysis of the RISING study.

The corresponding proportion in middle-C was between that in low/low-C and that in high/high-C for each time point. With regard to disease activity, an opposite trend was observed: The median DAS28-CRP was lowest in low/low-C and highest in high/high-C, although the difference (marginally significant) was observed only at W14 (8 weeks after the previous infusion).

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