Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer.

Interestingly, while none of the individual genes from the signature reached statistical significance when stroma surrounding benign glands in the prostates bearing high-Gleason and low-Gleason cancers was compared (sB.high-sB.low), the difference in ssGSEA scores for this comparison was marginally significant (Fig. 4b ; t -test, P = 0.08).

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