Noticeably, macroscopic examination of colons at the endpoint of the experiment on day 35 showed that ONX 0914 treated mice, as well as the Apc Min/+ LMP7 -/- mice developed none or decreased colorectal tumor incidences compared to vehicle treated mice in a highly significant manner (Figure 3D and 3E ).
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Inhibition and deficiency of the immunoproteasome subunit LMP7 suppress the development and progression of colorectal carcinoma in mice.
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