Genetic origin of α⁰-thalassemia (SEA deletion) in Southeast Asian populations and application to accurate prenatal diagnosis of Hb Bart's hydrops fetalis syndrome.

Validation of multiplex PCR assays for simultaneous detection of α 0 -thalassemia and SNP rs3760053 As shown in Table 2 , a highly significant difference ( P <0.001) in DAF between α 0 -thalassemia carrier and normal subject for the rs3760053 (T>G) was observed and G allele was strongly linked to the SEA deletion α 0 -thalassemia in this population.

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