Relationship between Factor V Leiden Gene Variant and Risk of Ischemic Stroke: A Case-Control Study.

Analysis as per subtypes of stroke according to the Trial of ORG 10172 in Acute Stroke Treatment classification discerned a borderline significant relationship in large vessel disease (LVD) subtype of IS in unadjusted (OR, 2.91; 95% CI 0.86–9.75) and significant relationship in adjusted analysis (OR, 5.17; 95% CI 1.32–20.3).

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did not find any significant association between Factor V gene polymorphism and risk of young stroke.[ 14 ] The strength of association in this study was close to significance (OR 1.37, 95% CI 0.94–1.97).

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in 2010 demonstrated a significant association of Factor V gene polymorphism and the probability of developing stroke only in selected studies in which patients were increased likelihood of prothrombotic involvement (OR 2.73, 95% CI: 1.98–3.75) with significant heterogeneity.[ 6 ] However, borderline significance was observed in “unselected” IS studies (OR, 1.40, 95% CI: 0.99–1.95).

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