ADPase CD39 Fused to Glycoprotein VI-Fc Boosts Local Antithrombotic Effects at Vascular Lesions.

23 In pigs, 700 μg/kg solCD39 increased bleeding times but achieved only a nonsignificant trend to attenuate platelet and fibrin deposition after coronary balloon injury. 21 In our study, we combined soluble forms of CD39 and GPVI‐Fc to form a recombinant, bifunctional protein, GPVI‐CD39, to investigate platelet‐mediated thrombus formation.

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GPVI‐CD39 exhibited a highly significant, dose‐dependent inhibition of platelet aggregation induced by 12 μg/mL collagen isolated from rabbit aorta (Figure 2 A).

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