High-level dietary cadmium exposure is associated with global DNA hypermethylation in the gastropod hepatopancreas.

PLoS One · 2017 · PMC5587323 · PMID 28877233

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an obvious trendno p-value reported

An obvious trend of increasing 5mC levels was observed starting at 28 days of exposure to the second highest dose and this trend persisted at the two highest treatments for close to one month, when the experiment was terminated after 56 days.

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an overall trendno p-value reported

These data indicate an overall trend towards DNA hypermethylation with elevated Cd exposure.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.