Barely Significant
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Mediator binds to boundaries of chromosomal interaction domains and to proteins involved in DNA looping, RNA metabolism, chromatin remodeling, and actin assembly.

Nucleic Acids Res · 2017 · PMC5587782 · PMID 28575439

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The sentences

extremely significantP -values < 10 −4actually significant
The difference between the occupancy levels of these proteins in the two classes of CID boundaries is extremely significant ( Supplementary Figure S6B ; two-sample t -test P -values < 10 −4 in all cases).

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