TLR2 activation induces antioxidant defence in human monocyte-macrophage cell line models.

Preincubation with the TLR2 agonist caused a highly significant increase in H 2 O 2 resistance in both exposed cell lines (Figure 1 ): in THP-1 the increase in IC50 was more pronounced in the undifferentiated cells (from 1.12 ± 0.02 mM in non-activated cells to 1.50 ± 0.05 mM after pam3CSK4 activation) than in differentiated ones (from 1.84 ± 0.10 mM in non-act

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