A general mechanistic model enables predictions of the biological effectiveness of different qualities of radiation.

However, there are some suggestions that these effects may be significant for some cells – such as homologous recombination defective cells, where RBEs are systematically under-estimated by the model – which suggests it would be desirable to link the model to more realistic DSB damage distributions provided by appropriate biophysical models, supported by more accurate models of DNA repair which take into account the effects of DSB interactions and misrepair on the repair kinetics and other mechanistic endpoints.

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