However, after stratification by colorectal subsite, the VDR gene exhibited a marginally significant association with the DFS among patients with rectal cancer (Global P =0.037), while the CASR gene was related to OS in colon cancer patients at a significance level of 0.05 (Global P =0.014).
For the VDR gene, the haplotype A-T-G in LD block 1 (rs11574143-TaqI-BsmI), which contained the borderline significant BsmI risk G allele from previous single SNP analysis, was associated with a reduced OS of rectal cancer in comparison to the most common haplotype (HR, 2.53; 95% CI, 1.20–5.34; block global P =0.027), although this association was no longer significant when Bonferroni’s correction was applied.