Concentrations of 7-DHC above the 95 th percentile (5.4 ng/mL, OR 2.4, 95% CI 1.6–3.6, adjusted- p <0.001) and desmosterol concentrations below the 5 th percentile (1.9 ng/mL, OR 1.9, 95% CI 1.2–2.9, adjusted- p 0.053) were associated with depressive symptoms of at least moderate severity, albeit the multiple hypothesis testing corrected p value for desmosterol was on the margin of significance.
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Plasma sterols and depressive symptom severity in a population-based cohort.
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The sentences
Concentrations of desmosterol, 5,6β-epoxycholesterol, and 25-hydroxycholesterol were significantly correlated with QIDS-SR 16 scores after Holm’s correction for multiple comparisons, while adjusted p values for cholestanol and 14-desmethyl lanosterol were close to significance ( Table 6 ).