Regulation of the glucocorticoid receptor via a BET-dependent enhancer drives antiandrogen resistance in prostate cancer.

The specificity of the bio-JQ1 signal was confirmed by BRD4 ChIP-seq which showed binding of the well-known JQ1 target BRD4 at precisely the same locus ( Figure 4A ) as well as by the highly significant correlation of bio-JQ1 with H3K27ac ( Figure 4—figure supplement 1A ).

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