First-line selective internal radiotherapy plus chemotherapy versus chemotherapy alone in patients with liver metastases from colorectal cancer (FOXFIRE, SIRFLOX, and FOXFIRE-Global): a combined analysis of three multicentre, randomised, phase 3 trials.

This finding contrasts with that from the EORTC CLOCC study, 6 which showed that a significant effect of radiofrequency ablation with or without surgery on progression-free survival translated into a highly significant overall survival benefit in patients who did not have primary tumour in situ or extrahepatic metastases at trial entry.

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