Heparan sulfate proteoglycans present PCSK9 to the LDL receptor.

Nat Commun · 2017 · PMC5593881 · PMID 28894089

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highly significantno p-value reported

Interestingly, individuals harboring a PCSK9 LOF variant in which R93 is substituted for cysteine (R93C) display highly significant reductions in LDL cholesterol and are protected against CAD 21 , 22 .

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