Arsenic and nicotine co-exposure lead to some synergistic effects on oxidative stress and apoptotic markers in young rat blood, liver, kidneys and brain.

However, co-exposure of arsenic and nicotine together demonstrated a highly significant arsenic accumulation in blood and kidney and a marked reduction in liver concentration in comparison to only arsenic exposed groups, indicating the influence of nicotine on the arsenic levels . 3.9 Effect on liver and brain antioxidant mRNA expression in rats ( Fig. 8 , Fig. 9 , Fig. 10 ) Brain catalase transcript level showed decreased expression but it was not statistically significant.

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