Most strikingly, a highly significant downregulation of CD16 on NK cells from ascites was observed, whereas CD16-expression on peripheral cells was very similar between patients and normal donors ( Fig. 1F , see Table S1 for MFI values).
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Soluble NKG2D ligands in the ovarian cancer microenvironment are associated with an adverse clinical outcome and decreased memory effector T cells independent of NKG2D downregulation.
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