Transformation in pretreatment manifestations of Gaucher disease type 1 during two decades of alglucerase/imiglucerase enzyme replacement therapy in the International Collaborative Gaucher Group (ICGG) Gaucher Registry.

3.3 Bone manifestations In each age group, there was a highly significant excess of key manifestations of bone disease (bone crisis, ischemic bone events, and bone pain) in splenectomized patients compared to patients with intact spleen ( P < .0001, Supporting Information Figure S1) with data collapsed across all 4 treatment initiation eras.

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