CRAMP deficiency leads to a pro-inflammatory phenotype and impaired phagocytosis after exposure to bacterial meningitis pathogens.

In CRAMP-KO microglia, exogenous CRAMP failed to increase HO-1 immunofluorescence density whereas interestingly co-stimulation of CRAMP with NM supernatant induced a statistically highly significant increase of HO-1 immunofluorescence density compared to CRAMP-WT microglial cells (Fig. 6e ).

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