Loss of MAPK-activated protein kinase 2 enables potent dendritic cell-driven anti-tumour T cell response.

Whereas the majority of the intratumoural T cell pool in LPS + tumour antigen-immunized mice did not express either receptor, we nevertheless observed a significant decline in PD-1 − TIM-3 + cells and an overall trend towards reduced inhibitory receptor expression upon CD11c + lineage-specific MK2 knock-out (Fig. 6a ).

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