Genetic polymorphisms in key methotrexate pathway genes are associated with response to treatment in rheumatoid arthritis patients.

Pharmacogenomics J · 2013 · PMC5604731 · PMID 22450926

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of borderline significanceno p-value reported

Five SNPs were significantly associated with adverse events; three in the DHFR gene (rs12517451, rs10072026, and rs1643657) and two of borderline significance in the FPGS gene.

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highly significantno p-value reported

Both SNPs in the FPGS gene (rs1054774 & rs4451422) were highly significant under a recessive model of inheritance (OR 3.03, 95% CI 1.14-7.99 and OR 3.60, 95% CI 1.39-9.33 respectively) ( Table 3 ).

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