Predictors of responses to immune checkpoint blockade in advanced melanoma.

Although the aforementioned correlations between immune parameters and in vitro/ex vivo response patterns were weak (in the sense that they were only borderline significant), we hypothesized that PD-L1 and/or CD95 on circulating CD4 + and CD8 + T cells might predict resistance to CTLA-4 blockade in MMel.

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When compensating/normalizing to the IgG or control medium, and thus making the data comparable and directly exploitable for the immunometrics scoring, the intraclass correlation remained highly significant (ICC = 0.84 (Pt12) and 0.87 (Pt24)) across all axes considered in the study.

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