Barely Significant
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An autism spectrum disorder-related de novo mutation hotspot discovered in the GEF1 domain of Trio.

Nat Commun · 2017 · PMC5605661 · PMID 28928363

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closest p · 0.0× alpha
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The sentences

highly significantP -value of < 1.96 × 10 −8actually significant
In the present study, our much larger case number (4890 for ASD-related disorders) and the large number of missense mutations identified in TRIO (11 ASD cases, as compared to 1.07 cases expected for the same number of individuals in the general population) dramatically improved the statistics, leading to a highly significant whole genome association of TRIO with ASD-like syndromes ( P -value of < 1.96 × 10 −8 ; Supplementary Table 3 ).

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