Overexpression of Chromosome 21 miRNAs May Affect Mitochondrial Function in the Hearts of Down Syndrome Fetuses.

Int J Genomics · 2017 · PMC5605795 · PMID 29057256

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closest p · 0.0× alpha

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boldest claim

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highly significantP < 0.0001actually significant

Over-representation analysis (ORA) of these lists, performed using the Web-based GEne SeT Analysis Toolkit ( http://www.webgestalt.org ) [ 33 ], demonstrated a highly significant enrichment ( P < 0.0001) of the cell component gene ontology category “mitochondrion” for let-7c-5p and miR-155-5p downregulated targets, with a cluster of 26 and 8 genes, respectively (Tables 1 and 2 ).

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