Barely Significant
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Role of the sigma-1 receptor chaperone in rod and cone photoreceptor degenerations in a mouse model of retinitis pigmentosa.

Mol Neurodegener · 2017 · PMC5606113 · PMID 28927431

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highly significantno p-value reported
As it is not yet practical to correct RP mutations individually, investigation of a common pathway, e.g., S1R, a target suitable for pharmacological interventions [ 6 ], is highly significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.