HIF-1α is a key regulator in potentiating suppressor activity and limiting the microbicidal capacity of MDSC-like cells during visceral leishmaniasis.

PLoS Pathog · 2017 · PMC5608422 · PMID 28892492

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highly significantno p-value reported

Surprisingly, we observed a highly significant reduction in the percentage of Ly6C hi cells harboring parasites in HIF-1α-deficient monocytes ( Fig 7F and S7A Fig ), independently whether they were pulsed or not with IFNγ.

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