DNA fragmentation factors 40 and 45 (DFF40/DFF45) and B-cell lymphoma 2 (Bcl-2) protein are underexpressed in uterine leiomyosarcomas and may predict survival.

According to Hwang et al, Bcl-2 expression was a strong favorable prognostic factor in the HR(+)/HER2(−) subtype of breast cancer and a marginally significant favorable prognosticator in the HR(+)/HER2(+), but had no prognostic impact on other subtypes. 29 In contrast, no significant correlation was seen between Bcl-2 expression and clinicopathological parameters of colorectal cancer. 26 Lack of Bcl-2 expression was also shown to be an independent predic

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