highly significantP < 0.001
Splenocytes from mice immunized with multivalent DNA vaccines pV273- sod , pV278- sod, or pV273-278- sod significantly increased IFN- γ production after being stimulated with 2 or 10 μ g/ml of recombinant proteins, reaching highly significant P values when compared to control groups PBS and pVAX ( P < 0.001) ( Figure 3(a) ).