CB1 Receptor Activation on VgluT2-Expressing Glutamatergic Neurons Underlies Δ⁹-Tetrahydrocannabinol (Δ⁹-THC)-Induced Aversive Effects in Mice.

2E , t = 0.79, p > 0.05), but a marginally significant difference in staining density per cell (Fig. 2F , t = 1.38, p = 0.05), suggesting that CB1 mRNA level is higher in VTA glutamatergic neurons than in VTA GABAergic neurons. Δ 9 -THC produces conditioned place aversion in mice We then used the conditioned place preference (CPP) or aversion (CPA) procedures to compare the rewarding or aversive effects of Δ 9 -THC between VgluT2- CB1 ‒/‒ mice and their wildtype control littermates.

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