Results : As a result of GWAS in surgical patients, a SNP mapped to 1q32, rs2076222 had highly significant associations with postoperative analgesic requirements; the subjects with the C allele (A/C and C/C) required more fentanyl and more rescue analgesics for postoperative analgesia, compared with those without this allele (A/A), while C allele carriers tended to report higher pain scores during the early postoperative period, compared with non-carriers.
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PT641. Genome-wide association study identifies candidate loci associated with postoperative fentanyl requirements after laparoscopic-assisted colectomy
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