ONC201 selectively induces apoptosis in cutaneous T-cell lymphoma cells via activating pro-apoptotic integrated stress response and inactivating JAK/STAT and NF-κB pathways.

Along with the preclinical efficacy evidence and absence of toxicity, the coordinate disruption of key signaling pathways by ONC201 that are of highly significant relevance in the pathophysiology of CTCL warrants the clinical examination of ONC201 in advanced CTCL.

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