Transcriptome analysis reveals differences in mechanisms regulating cessation of luteal function in pregnant and non-pregnant dogs.

Lists of representative genes involved in particular GO terms in each contrast are presented in Additional file 5 . “Luteal regression over luteolysis”: GO terms having highly significant association with genes upregulated in the luteal regression group are: extracellular matrix ( p = 5.52e-05) and matrix organization ( p = 0.001), steroid hormone mediated signaling ( p = 2.29e-04) and steroid hormone receptor activity ( p = 1.63e-04), regulation of gene expression ( p = 7.40e-04), negative regulation of transcription from RNA polymerase II promoter ( p = 5.02e-05), and regulation of transcription, DNA-templated ( p = 2.45e-04), as well as positive regulation of epithelial cell proliferation ( p = 3.4e-03).

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