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Efficacy and safety of non-vitamin K antagonist oral anticoagulants compared with warfarin in patients with atrial fibrillation.

Open Heart · 2017 · PMC5623334 · PMID 29018536

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When the analysis was confined to haemorrhagic stroke, that is intracerebral and subarachnoidal bleeding events, which constituted a little less than half of all intracranial bleeding events, the apparent benefit of NOACs did not quite reach statistical significance (SHR 0.71, CI 0.51 to 1.01).

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