Optimization of phenolics and flavonoids extraction conditions of Curcuma Zedoaria leaves using response surface methodology.

Based on the results, it showed that the model is highly significant when the computed F -value is greater than the tabulated F -value and the probability value is low ( p < 0.0001 ) indicating that the individual terms in each response model were significant on the interaction effect.

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[ 27 ] where the flavonoid content increased when the temperature of extraction increased to below 70 °C and exhibited a decreasing trend above the optimum level of temperature.

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