Higher patient satisfaction with antidepressants correlates with earlier drug release dates across online user-generated medical databases.

Clinical Pharmacology disease management patient‐generated online data Pharmacometrics Psychopharmacology For major depression, the same relationship was even more pronounced, with an average loss of 0.4 rating points out of 10 per decade since the FDA approval (corresponding to a Pearson's R of between −0.56), highly significant for all drugs with at least five reviews ( P ≤ 0.0001), at least 10 reviews ( P ≤ 0.0001), or at least 20 reviews ( P = 0.0002) (Table 2 ).

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