Recombinant vaccines of a CD4+ T-cell epitope promote efficient control of Paracoccidioides brasiliensis burden by restraining primary organ infection.

As had been observed at day 75, lungs of rAdPbT/rAdPbT- and rAdPbT/rPbT-immunized mice also secreted the highest levels of IL-12 compared to mock-immunized mice at day 105 ( Fig 4A ), while all other mice immunized with P10-based formulations displayed levels of this cytokine that were not statistically different (a borderline significance was observed in some cases for group rPbT/rAdPbT).

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IFN-γ or TNF-α secretion was not statistically different after challenge among infected mice ( Fig 3B and 3C ) although differences were highly significant when compared to non-infected animals, suggesting that Pb18 infection strongly boosts production of these cytokines in all animals masking any previous differences due to vaccination.

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