Frequency of regulatory T cells determines the outcome of the T-cell-engaging antibody blinatumomab in patients with B-precursor ALL.

Leukemia · 2017 · PMC5629361 · PMID 28119525

Europe PMC DOI

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marginal significanceno p-value reported

In each step the LRT (likelihood ratio test) has been used to assess marginal significance, and nonsignificant (significance threshold P <0.05) covariates have been dropped iteratively.

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highly significantno p-value reported

LDH in particular showed a highly significant increase in the non-responder group (median 402.5 UI/l) compared with the responder group (median 211.5 UI/l).

also in 132,142 other papers

borderline significantno p-value reported

The full model (including all five significant covariates) detected a borderline significant risk association only for TregPercentageCD25FOXP3, whereas gender, LDH Treg/CD3 and bone marrow blast infiltration remained insignificant.

also in 11,409 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.