Enhancing excitatory activity of somatosensory cortex alleviates neuropathic pain through regulating homeostatic plasticity.

Applying the optogenetic stimulation to unilateral S1 for two sessions of 3 hours daily results in a highly significant decrease in mechanical hypersensitivity of bilateral hind-paws, and this effect was significant as early as 3 days after tSCI and remained stable throughout the stimulation period (Fig. 4A , p < 0.001 for both sides, repeated-meaure ANOVA followed by Bonferroni tests, n = 6 mice in each group).

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