Genetic and environmental risk factors for rheumatoid arthritis in a UK African ancestry population: the GENRA case-control study.

Rheumatology (Oxford) · 2017 · PMC5638023 · PMID 28407095

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highly significantP = 8.1 × 10 − 9actually significant

In GENRA/SLESS one further haplotype was observed, which was not present in Europeans [encoded by HLA-DRB1 *14:04; MAF = 0.005; OR = 0.96]. Omnibus tests showed highly significant associations for amino acid positions 11 and 13 in HLA-DRβ1 ( P = 8.1 × 10 − 9 , P = 7.8 × 10 − 9 , respectively) and case–control status in GENRA/SLESS, but not positions 74 ( P = 0.017) and 71 ( P = 0.20).

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