Systematic, network-based characterization of therapeutic target inhibitors.

Alternatively, the protein regulon may be inaccurate, or the compound’s polypharmacology may be significant resulting in a vast set of secondary effects involving other proteins.

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Only 72714 samples have highly significant reproducibility with z-score bigger than 5, from where 1,365 compound’s treatment signatures and 92 shRNA mediated silencing signatures were selected for further analysis.

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